This Site and Store is Hosted by:
www.Cybrhost.com
6133 Rockside Rd., Suite 301
Independence, OH 44131
|
|
|
NO LONGER AVAILABLE - WILL BE REPLACED BY MAY 1, 2010 WITH A SUPERIOR PRODUCT
CO-ENZYME Q10 PLUS
Co-enzyme Q10 (Co-Q10) is a Vitamin-like substance that is
found in virtually all cells of the human body, thus earning
Co-Q10 its other name, ubiquinone. Unlike vitamins, which by
definition are not synthesized within the body, Co Q10 is
synthesized in nearly every tissue of the body. It is also, in
fact, not a vitamin at all but rather a co-enzyme - an organic
molecule that activates a larger protein catalyst (an enzyme)
that in turn facilitates a biological reaction without
extinguishing itself within that reaction.
Co-enzyme Q10 has a quinone-like group (hence the Q) with 10
isoprenoid units as the side-chain (hence the 10). Quinones are
molecules that serve as electron receptors in essential biological
functions such as photosynthesis and respiration. Co-Q10’s quinone
ring is synthesized from the amino acid tyrosine whilst the
isoprenoid side chains are formed from acetyl CoA (of which
pantethine is also a precursor). Co-Q10 is very similar in structure
to Vitamin K and Vitamin E, although its role is quite different.
Co Q10 is a fat-soluble, crystalline compound with a Molecular
weight of 338.44 Daltons. Co Q10 functions as a co-enzyme in the
energy-producing metabolic pathways of every cell of the body with a
powerful antioxidant activity.
Biological functions
The fact that Co-Q10 is able to accept electrons in such a
ubiquitous manner means that that it can serve several key
biological functions pertinent to human health. These include:
(1.) The Generation of ATP: Co Q10 is critical in generating the
synthesis of ATP (or adenosine triphosphate, the energy “currency”
of all cells). This process takes place in the mitochondria and
involves an intricate and complex cascade of enzymatic reactions
called the “electron transfer chain”. Indeed, Co-Q10 is most notably
found in the inner membrane of the mitochondrion.
(2.) Acts as a Redox agent. Co Q10 keeps other antioxidants (e.g.
vitamins E and C) in their reduced active states. For example, as
vitamins C and E perform their functions as antioxidants, they
themselves become oxidized. Since these vitamins are active in their
reduced forms, Co Q10 recharges them (reduces them) to their active
states by accepting electrons.
(3.) Antioxidant activity. Biological oxidation is a ubiquitous
event that occurs continually in the body, causing havoc and
numerous pathological conditions. Oxidation results from the
breakdown of oxygen molecules as they combine with other molecules
in the body. Such oxidation can be the result of the body’s normal
metabolism of the foods we eat, or it can occur in the body as a
result of external forces such as exercise, radiation, pollution,
alcohol or heavy metal intoxication, infections etc. The resulting
free radicals are highly reactive molecules, which interfere with
enzymatic reactions and cause disruption of cell membranes and even
DNA. Co-Q10 has a strong ability to give up electrons quickly and
thus acts as a powerful antioxidant against free radicals, and
affords protection against LDL oxidation, which is a pivotal step in
the cause of atherosclerosis. Co-Q10 also stabilizes cell membranes
and platelets.
The use of Co-Q10 as adjunctive therapy in the treatment of heart
failure goes back decades. In fact, Co-Q10 has been approved as a
drug in Japan for the treatment of congestive heart failure since
1974, with a number of other nations following suite.
Placebo-controlled studies to date with Co-Q10 (including one study
conducted in Italy which included 2,664 patients with congestive
heart failure) have produced what scientists call ‘significantly
positive results’. These results include diminished levels of
fatigue, chest pain, dyspnea and palpitations. Treatment with Co-Q10
was even able to restore normal heart size and function in some
patients - primarily those whose onset of congestive heart failure
was relatively recent.
There have also been many studies examining the effect of Co-Q10 as
an addition to standard medical treatments, particularly those
pertaining to hypertension and other manifestations of
cardiovascular disease. When Co-Q10 was added as a concurrent
treatment alongside the standard drug therapies for these
conditions, the result was a significant reduction in the required
use of the aforementioned drug therapies in order to alleviate the
conditions in question.
Ensuring Absorption:
A critical point to remember is that Co-Q10 is fat-soluble, and that
absorption of Co-Q10 has always been a challenge. In fact, well over
60% of orally consumed Co-Q10 is excreted in bowel movements and its
absorption is not only variable but also dependent on food intake,
particularly the lipids present in the food. Absorption is lower
when Co-Q10 is consumed on an empty stomach and higher when taken
with food that is comprised of high lipid content. In order to
overcome this potentially serious impediment to absorption, AOR™ has
introduced Co-Q-PLUS™. Co-Q-PLUS™ provides a potent 100mg of
Coenzyme Q-10 (ubiquinone) in a softgel comprised of a superior
lipid-based delivery system to ensure maximum absorption.
Complications
None reported. Shown to be useful with Beta-blockers, psychotropic
drugs including phenothiazines and tricyclic antidepressants. A 1994
Lancet study reported 3 cases where Co Q10 reduced the effect of
coumadin. No other cases have been reported. It may be wise to
monitor the prothrombin when supplementing with Co Q10.
References
Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco
S, Lyon W, Esmore D. “Improved outcomes in coronary artery bypass
graft surgery with preoperative coenzyme Q10: a randomized,
double-blind, placebo controlled trial.” (In: “Coenzyme Q10 protects
the aging heart against stress: studies in rats, human tissues, and
patients.”). Ann N Y Acad Sci 2002 Apr; 959: 355-9.
Singh RB, Wander GS, Rastogi A, Shukla PK, Mittal A, Sharma JP,
Mehrotra SK, Kapoor R, Chopra RK. “Randomized, double-blind
placebo-controlled trial of coenzyme Q10 in patients with acute
myocardial infarction.” Cardiovasc Drugs Ther. 1998 Sep; 12(4):
347-53.
Sacher HL, Sacher ML, Landau SW, Kersten R, Dooley F, Sacher A,
Sacher M, Dietrick K, Ichkhan K. “The clinical and hemodynamic
effects of coenzyme Q10 in congestive cardiomyopathy.” Am J Ther.
1997 Feb-Mar; 4(2-3): 66-72.
Okuma K, Furuta I, Ota K. “Protective effect of coenzyme Q10 in
cardiotoxicity induced by adriamycin.” Gan To Kagaku Ryoho. 1984
Mar; 11(3): 502-8.
Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study
on the safety and efficacy of coenzyme Q10 as adjunctive therapy in
heart failure. Mol Aspects Med. 1994; 15(Suppl):287-294.
Burke BE, Neuenschwander R, Olson RD. “Randomized, double-blind,
placebo-controlled trial of coenzyme Q10 in isolated systolic
hypertension.” South Med J. 2001 Nov; 94(11): 1112-7.
CO-ENZYME Q10 PLUS |
| Quantity in Basket:none
Code: 1518
Price:$0.00
Shipping Weight: 0.00 pounds
|
|
| | 60 Capsules |
DISCUSSION: CoQ10 has been shown to be an effective aid for
the support of cardiovascular disease and is a well-known
antioxidant. CO-Q PLUS is formulated with a superior
lipid-based delivery system to ensure maximum absorption.
60 Softgels
100 mg
_____________________________________________________________
SUPPLEMENT FACTS:
Serving Size: 1 Softgel
Co-Enzyme Q10 (ubiquinone-10)................... 100 mg
_____________________________________________________________________
Other ingredients: Rice Bran Oil, gamma tocopherol. Softgel:
gelatin, glycerin, water, carob.
AOR guarantees that no ingredients not listed on the label have been
added to the product. Contains no wheat, gluten, corn, nuts, dairy,
eggs, fish, or shellfish.
Suggested Use:
Take one to three capsules daily with food, or as directed by a
qualified health practitioner.
Main Applications:
* Heart conditions
* Periodontal disease
* Immune disorders
* Cancer
* Blood sugar control
Pregnancy / Nursing
No studies, best to avoid.
Cautions:
CoQ10 may decrease the effectiveness of warfarin; consult a health
practitioner prior to taking this supplement if you are on warfarin.
*These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat,
cure, or prevent any disease.
|
|
|
