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NATTOKINASE: A Potent Fibrinolytic Enzyme Extract of Traditional Japanese Food; Landmark Development
for Cardiovascular Health



What Is Nattokinase?

Nattokinase is a potent fibrinolytic enzyme extracted and highly purified from a traditional Japanese food called natto. Natto is a fermented cheese-like food that has been used in Japan for over 1000 years for its popular taste and as a folk remedy for heart and vascular diseases. Natto is produced by a fermentation process by adding Bacillus subtilis var. natto. a benefical bacteria, to boiled soybeans. The resulting nattokinase enzyme, is produced when Bacillus siibtilis var. natto acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that contains the specific nattokinase enzyme.

Potent Thrombolytic Activity

The human body produces several types of enzymes for making thrombus, but only one main enzyme for breaking it down and dissolving it - plasmin. The properties of nattokinase closely resemble plasmin. According to Dr. Martin Milner, N.D. from the Center for Natural Medicine in Portland, Oregon, what makes nattokinase a particularly potent treatment, is that it enhances the body's natural ability to fight blood clots in several different ways; Because it so closely resembles plasmin, it dissolves fibrin directly. In addition, it also enhances the body’s production of both plasmin and other clot-dissolving agents, including urokinase (endogenous), “in some ways, Dr. Milner says nattokinase is actually superior to conventional clot-dissolving drugs. T- PAs (tissue plasminogen actuators) and urokinase (the pharmaceutical agents) are only effective when taken intravenously (IV) and often fail simply because a stroke or heart attack victim^ arteries have hardened beyond the point where they can be treated by any other clot-dissolving agents Nattokinase however can help prevent that hardening with an oral dose of as little as 100 mg a day.1,7

The Prolonged Action of Nattokinase

Nattokinase produces a prolonged action (unlike antithrombin drugs that wear off shortly after IV treatment is discontinued) in two ways: it prevents coagulation of blood and it dissolves existing thrombus. Both the efficacy and the prolonged action of NK can be determined by measuring levels of euglobulin fibrmolytic activity (EFA) and fibrin degradation products (FDP), which both become elevated as fibrin is being dissolved. By measuring EFA & FDP levels, activity of NK has been determined to last from 8 to 12 hours. An additional parameter for conflrming the action of NK following oral administration is a rise in blood levels of TPA antigen (tissue plasminogen activator), which indicates a release of TPA from the endothelial cells and/or the liver5'7

The Mechanism Behind Thrombus

Blood clots (or thrombi) form when strands of protein called fibrin accumulate m a blood vessel, In the heart, blood clots cause blockage of blood flow to muscle tissue. If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies. This can result in angina and heart attacks. Clots m chambers of the heart can mobilize to the brain, In the brain, blood clots also block blood and oxygen from reaching necessary areas, which can result in senility and/or stroke. 1 Thrombolytic enzymes are normally generated in the endothelial cells of the blood vessels. As the body ages. production of these enzymes begins to decline, making blood more prone to coagulation. This mechanism can lead to cardiac or cerebral infarction, as well as other conditions. Since endothelial cells exist throughout the body, such as in the arteries, veins and lymphatic system. poor production of thrombolytic enzymes can lead to the development of thrombotic conditions virtually anywhere in the body.7

Nattokinase

Nattokinase Quantity in Basket:none
Code: 6501
Price:$0.00

Shipping Weight: 0.00 pounds
 
Quantity:
90 Vegi-Caps
Glossary of Terms:
Cardiac Infarction: Heart attack.
Cerebral Infarction: Stroke
Fibrin: A whitish, filamentous protein formed by the action thrombin on fibrinogen and makes up part of coagulum or blood clots.
Fibrinolytic: Pertaining to or causing the breaking up of blood clots.
Infarction; Cardiac or cerebral time death due to failure of blood supply to the area usually caused by a blood clot.
Plasmin; An endogenously produced fibrinolytic enzyme,
PIasminogen; A precursor to plasmin. A protein found in many tissues and body fluids.
Thrombus: A blood clot that obstructs a blood vessel or a cavity of the heart.
Thrombolytic: Pertaining to or causing the breaking up of a thyombus.
TPA: Tissue plasminogen activate
t-PAs; The most commonly used thrombolytic drugs including activase, urikonase, and streptokinase.
Urokinase: An endogenously produced thrombolytic enzyme & also a commonly used thrombolytic drug giver intravanously to cardiac and cerebral infarction patient.

References:
1. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute March 2002.
2. MaruyamaM, Sumi H. Effect of Natto Diet on Blood Pressure JTTAS, 1995.
3. Sumi H. Hamada H, Nakanishi K, Hiratani H, Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase Acta Haematol 1990:84(3:139-43.
4. Sumi H, Hamada H, Mihara H. A novel strong flbrinolytic enzyme (nattokinase) in the vegetable cheese "natto " International 5 Journal of Fibronolysis and Thrombolysis. Abstracts of the ninth international congress on fibrinolysis, Amsterdam, 1988. Vol 2, Sup,1:67.
5. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinotytic emyme (nattaknase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia 1987, Oct 1.5;43(10):1110-1
6. Sumi H. Healthy Microbe "Bacillus natto”. Japan Bio Science Laboratory Co. Ltd.
7. Sumi H. Interview With Doctor of Medicine Hirayuki Sumi, Japan Bi0 Sience Laboratory Co. Ltd.
8. Sumi H. Structure and Fibronolytic Properties of Nattokinase.

© 2010 Dr Deb. All rights reserved


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