As
a result, your body absorbs Benfotiamin better than thiamin
itself, and levels of thiamin and TPP remain higher for longer.
Thiamin absorption from Benfotiamin is about five times as
great as from conventional thiamin supplements. And the effect
is even more impressive at the tissue level: brain and muscle,
for instance, take in five- to twentyfive-fold as much thiamin
in the form of allithiamines as they do of an equal amount
of regular thiamin.
And
Benfotiamin is even more bioavailable than the other allithiamines,
including thiamin tetrahydrofurfuryl disulfide/TTFD. Yet Benfotiamin
is actually less toxic than conventional thiamin supplements!
By effectively increasing levels of thiamin itself, Benfotiamin
dramatically boosts AGE-fighting thiamin pyrophosphate and cell-shielding
transketolase activity in your body.
Shielding Nerve Structure
While most "anti-AGE" supplements rely on test-tube "browning" experiments
as the "evidence" of efficacy, Benfotiamin has been
proven in multiple real-world human and animal studies to reduce
AGE formation and support tissue structure and function in diabetics.
Most impressively, many randomized, double-blind, placebo-controlled
human trials have proven that Benfotiamin powerfully supports
nerve function in diabetic neuropathy. In one trial, 24 people
suffering with diabetic neuropathy took either Benfotiamin (plus
doses of common B6 and B12 similar to those used in mutivitamins)
or a look-alike dummy pill, spread out into three pills over
the course of the day, for twelve weeks.
The
participants started with 320 milligrams of Benfotiamin per
day for the first two weeks, followed by 120 milligrams for
the rest of the trial. Before and after the trial, the function
of patients's nerve cells were tested using nerve conduction
velocity (NCV) and vibratory perception threshold (VPT) (which
tests the nerves's sensitivity by determining the lowest level
at which vibrations applied at key nerve sites are first felt).
At the end of the trial, the vibration perception threshold had "clearly"
improved by 30 in those who had taken the Benfotiamin supplements,
while it had worsened in the placebo group by 5% at one site
and by 32% at another. At the same time, people taking Benfotiamin
experienced statistically significant improvements in nerve conduction
velocity from the feet, even as this aspect of nerve function
deteriorated in those taking the look-alike pills!
The
power of Benfotiamin to improve vibratory perception threshold
and nerve conduction velocity have been confirmed in other
trials. Clinical trials have also shown that Benfotiamin supports
nerve function in diabetics as measured by many other methods.
For instance, Benfotiamin users experience a 50% reduction
in diabetic nerve pain, along with an increased ability of
the nerves to detect an electrical current, respond to electrical
stimulation, and regulate the heartbeat.
Similarly,
Benfotiamin prevents this loss of control from happening in
the first place in diabetic dogs. In another human clinical
trial, a B-vitamin combination using Benfotiamin as its thiamin
source was put head-to-head with a B-complex supplement that
included a megadose of conventional thiamin. Benfotiamin proved
its effectiveness on several of these key parameters, while
the standard thiamin pill failed.
These benefits are not due to changes in blood sugar levels (either
fasting, or after a meal, or averaged over several months (as
measured by HbA1c), or improvements in metabolic benchmarks.
They are the direct results of Benfotiamin's AGE-fighting, metabolic-balancing
powers.....More
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