FIRST OF ALL...IF YOU WANT TO KNOW JUST HOW DANGEROUS DENTAL AMALGAMS ARE...WATCH THIS VIDEO!!
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Detoxification of mercury from within the body’s cells is probably one of the most controversial areas of alternative medicine today.
We must look at the processes involved in detoxification and support or augment them.
In order to cure someone, to restore health, a practitioner has to affect the mechanisms responsible for clearing the body of toxins and then reconstitute health.
Mitochondria are responsible for energy molecule production. Although the DNA of the mitochondria only total about 1% of the cell’s overall DNA (which by the way is completely inherited from your mother), it is about 20x more susceptible to toxic reactions.
These energy molecules, called ATP are manufactured by biochemically converting your nutrients such as glucose from carbohydrates, amino acids from proteins and fats through a long chain of reactions into ATP. Essentially these are the agents of energy or “life” to the human being (excluding the spiritual aspect, of course).
Although our genetics lead us to our susceptibilities, we now understand
as practitioners of true nutritional/biochemical medicine how to alter
a person’s chemistry to augment or bring out the best of our genetics.
Chronic illness stems from a cellular environment in which the proper
substances to maintain optimal genetic expression are lacking.
It interferes with the normal synthesis of proteins, causes organ dysfunction particularly within the kidney, liver and in some reports the thyroid.
It also has a devastating effect on the whole central nervous system and its nerve cells.
What we must remember is that damage to your mitochondria (the energy
production units of the cell) is accumulative over the years and increases
one’s risk to degenerative disease. By looking at the whole “picture”
in this light we are able to see how something like mercury can greatly
contribute to chronic “unwellness”.
I have been accused of being "10 years behind the times" because I refuse to opt into using the favourite "flavour of the month" with respect to protocols.
is NO one approach for every person; we are all different, came to our
illnesses through different routes, stresses, genetics, etc. I am saying
there are no magic bullets, or panacea to health. Anyone who claims
to have the perfect programme for all that suffer the same ailment is
by definition fraudulent and irresponsible.
Issues like parasites; Candida, CFS, Fibromyalgia etc are often a sequelae of Hg poisoning chemical pathways and leaving them in a state of dysfunction.
You can try as hard as you can to get rid of the symptoms, but within a very short time the patient will be dealing with the same problem until the metal is removed from their bodies and a path of permanent correction can begin.
Again, for this reason it is wise to have the help of a licensed practitioner and one who understands the need to treat this issue in "layers" and at the patient’s tolerance.
Many do not understand the mechanism of mercury toxicity and the careful, gentle therapy needed to return to health. I cannot say too often the need to proceed slowly, with caution, adding new items to the protocol as the patient responds and is ready.
Three favourite issues of the general "healers" or uninformed practitioners are Candida, Fibromyalgia and parasites associated with mercury patients.
Yes, of course, these syndromes co-exist and are often found in the same patients. It has been claimed that the prevalence of Candida in mercury patients is the body’s reaction to the metal and it over produces yeast and abnormal flora in the intestinal tract to "chelate" the metal and protect the body.
I remain not totally convinced this is actually the case. As a matter of fact, more recent studies show just the opposite.
What IS known is that mercury causes the production of abnormal flora, particularly anti-biotic resistant flora, which I believe, allows Candida to set up shop and go nuts.
The other issue is that mercury conflicts or “gets in the way of” normal protein synthesis and we rely on this process to make proteases - enzymes - which normally kill off yeast and parasites (and bacteria) in our intestinal tracts.
Therefore, what is the point of going through strict Candida/parasite/bacterial cleanses when the amalgams are still present...allowing it to regrow.
However, having said all that, there are some basic biochemical processes which must function relatively well, before the process of detox can begin. First and foremost is the ability of the liver to detoxify effectively.
Side Note: Most mercury toxic patients are or have been chronically ill. It is wise to remember that healing needs to occur in a relaxed, gentle atmosphere. I highly recommend the products at Serenity Health to facilitate what I am about to suggest for
25% of detox occurs in the intestines - the rest for the most part happens
in the liver. The liver clears more than 2 litres of blood every minute.
These cells do not normally create antibodies which would cause over reaction to antigens and hence allergies.
the liver is damaged however, filtration breaks down and more antibodies
are created especially to E. coli, other bacteria. Allergies to dietary
proteins such as gluten from wheat and casein or albumin from dairy
products also appear.
Often attention must be directed to healing the “leaky” digestive tract and the incompetant breakdown of food.
Doing therapy with Metagenics UltraInflammx or UltraInflavogen (Canada) to heal the gut, EPA/DHA 720 LEMON GELS, from Metagenics and Digestive Enzymes from Naturpharm is a great start. During this time eliminate wheat and dairy (except goat).
I usually suggest starting with 1/2 scoop in water or juice (not pineapple or citrus) at least 1/2 hour before meals, with one Fish Oil Concentrate and 2 Essential Balance at each meal. Take the digestive enzyme (M5, M6, M3, M4 or M7 according to need) at this time and with each meal.
I like to start a detox programme with a liver cleanse, particularly if there are sluggish bowel habits in the patient. I tend to use a combination of botanical remedies Herba-Lega-H Liver Drainage Tonic and homeopathic drainage remedies for the Herba-Lymph Lymphatic Drainage Tonic and Herba-Petro Kidney Drainage Tonic
Detox - Phase I and Phase II
To truly understand detoxification and what will be effective, one must comprehend the steps, which occur within the liver and supplement the needed co-factors. The liver essentially detoxifies in two phases, each one preparing the offending agent for expulsion by the liver into the feces.
Phase I - The toxin is made more water-soluble and more biochemically reactive. This is accomplished by a group of enzymes (about 150 of them) collectively called "cytochrome P450’s. In fact, at this stage the toxin is "opened" up by these enzymes so it will bind or conjugate with an acceptable substrate in Phase II, forming a complex the liver now recognized as foreign and will excrete via the bowels. There are a lot of free radicals produced in this process and we must have enough anti-oxidant present to offset it or else other implications to health will result.
support Phase I activity, I will add Oxygenics depending on the patient’s current health. The more
chemically sensitive the patient is - the more antioxidant protection
they need. It must however be added gradually, starting at only 1-2
capsules per day.
The addition of a good fibre product 2-4 capsules at bedtime not only helps this but assists in moving heavy metals and other toxins from the digestive trract.
Phase II - Conjugation
Glutathione is a very powerful antioxidant, functional in both phases of liver detoxification. If it is used up in Phase I in the free radical process as an antioxidant, then not enough is left for Phase II.
It is most important in the mitochondria of the cell, which is the organelle or structure within the cell responsible for taking glucose and oxygen and converting them through a long series of biochemical steps to ATP (adenosine triphosphate) the base engery molecule of your body.
Glutathione (GSH) is a very key player in the antioxidant mechanism of the cell, particularly the mitochondria. A large load of oxygen free radicals develop in the mitochondria, unavoidably from the biochemical production of ATP. This pathway is called Oxidative Phosphorylation (OP). Free radicals “leak” from the process of OP and randomly “fly” around the cell, creating havoc with other cellular structures and processess if not contained.
Some of these “free radical” structure’s names may be familiar to you. They include Superoxide, Peroxide and hydroxyl radical amongst others. They are VERY reactive and threaten important cellular components such as DNA, RNA, enzymes other proteins and even the phospholipids responsible for the integrity of the cell membrane. Healthy cells chemically oppose these free radicals and GSH is one of the main entities used to do this.
Science believes the ability or not of our bodies to handle these very reactive molecules determines organ and tissue deterioration over time and that equals “aging”.
Protection from external oxidants such as environmental pollutants is also a big function of GSH. Some of the worst contaminants in our society depend on our cells’ ability to handle exogenous or externally sourced toxins.
Cigarette smoke contains literally thousands of chemicals and one puff of smoke has some trillion free radicals in it. Your body’s Vitamin C and E literally die a miserable death and the tars which remain in the body go on creating free radicals for their life time.
Some of the over the counter drugs, which many consider relatively harmless such as acetaminophen, depletes GSH from liver cells, making the liver more susceptible to toxicity.
Even exercise can deplete GSH, because of the demand by the body to produce more ATP for energy.
This, in days gone by would have been counteracted by our diets...rich and full of nutrients, but unfortunately, today with processing and harvesting while not ripened..this is no longer the case. The ardent exerciser would be wise to include GSH in their diet.
A list of some of the other factors which depletes GSH would include:
Lifestyle choices such as stress, emotional and mental, alcohol, smoking, drug use (legal or illegal) can mix with exogenous toxins to produce no end of oxidative pathways which eventually deplete the body of GSH and other antioxidants, resulting in chronic illness.
It is for this reason, that mercury patients have to be looked at from all of these parameters to successfully detox and return them to health.
The liver, being the organ most involved with detoxing also is the main storage port for GSH. The cells of the liver are the most finely adapted to produce GSH from its precursors, to recycle it from its oxidized form GSSG and to actually use GSH to combat toxins.
It should be understood, though that a decent level of GSH in the liver does not necessarily mean your detox paths will be the best. In fact, our own GSH stores are meant to keep endogenous toxins under control and now with the world we live in to consider, one should pay attention to add other antioxidants, B Vitamins and minerals to your supplementation to aid GSH in its now overwhelming job.
According to studies, normal kidney functioning in terms of protein concentration and electrolyte concentration in the urine becomes impaired after amalgam placements. The kidney seems to respond differently to different metals and Hg (mercury) affects the proximal tubule within the kidney structure, which is responsible for the re-absorption of electrolytes such as sodium and potassium and the protein albumin. Increasing GSH and selenium levels in the kidney has a renal protective effect, mitigating the effects of Hg.
The brain (in particular) and the central nervous system (CNS) are highly oxygenated tissues and therefore very susceptible to free radical attack. They also contain a large amount of unsaturated lipids or fats..which are also prone to oxidation.
In the brain, GSH works with selenium to form glutathione peroxidase, which is the enzyme that removes mercury from the brain.
Inorganic and methyl mercury have a very high affinity for sulfhydryl groups-the sulphur containing molecules on some amino acids such as cysteine. Hg reacts intracellularly with these sulphur based groups found on glutathione, cysteine and histidine residues in proteins, which in turn allows for transport out of the cell of the offending mercury. In animal studies it was seen that mercury secrection into the bile was dependant on glutatione’s secretion into the bile, hence then, mercury’s excretion appears to rely on glutathione transport.
One of the major problems with glutathione is its availability for absorption. Studies have shown that using Vitamin C and N-Acetyl-cysteine can greatly assist in its uptake from the intestines.
Glutathione is often added to the protocol using undenatured whey. There are several of these products available, but the one I have had the most success with is GSH COMPLEX. I find the amount of mercury excreted as seen with fecal heavy metal testing from Doctor's Data in Chicago..much better with this product than any other. In independant lab tests..it out-preforms all others. For complete information see my GSH Page
Although our own internal processes of metabolising nutrients, etc. result in the usage of glutathione, for detoxification of end products, GSH is recovered from these pathways, recycled and reusable. When it is used to detox a foreign external substance (xenobiotic), it is lost in the process, requiring replenishment from our diet.GSH Complex provides the raw material necessary to fulfill this need.
Alpha Lipoic Acid
Alpha-lipoic acid is an incredible liver anti-oxidant. In Phase I, it acts in this capacity to scavenge and neutralize free radicals. It works in both the fatty and watery compartments of the body to quench free radicals. It is a facilitator of glutathione regeneration by up-regulating the enzyme pyruvate dehydrogenase right at the start of the tri-cyclic acid cycle..the process of using one’s glucose to manufacture energy molecules NADH and ATP. These energy molecules are essential to life and all of its biochemical processes. One very important note, peculiar to this discussion is the conversion of oxidized glutathione (the “used” form GSSG) to the reduced or active form (GSH) where it can act again in our cells’ favour.
Studies seem to indicate that ALA is particularly good at enhancing glutathione levels in the nervous system.
Because ALA is also a dithiol...that is has two sulphur groups in its structure, it is also a chelator of Hg. The difference is that it is true that is does not chelate as strongly as the pharmacological chelators DMSA and DMPS, it is very lipophilic meaning it has affinity to the fatty tissues of the body, so has the potential to increase mercury in areas such as the central and peripheral nervous system if used in high quantities. Used in moderate, regular doses it can get to hydrophobic (lipid containing) compartments these other chelators cannot.
In a detox protocol, it is best to add this in any significant amount (over 50mg. per dose) after detoxing for 4-6 weeks. This is after the last amalgam has been removed. If you did some natural detox before removals..don't count this in the 4-6 weeks.
It has also been suggested that taking it every 3-4 hours around the clock to keep blood levels stable works best. (Dr. Andrew Cutler firstname.lastname@example.org) I use Lipoic Acid ..you can click on the link to read detialed information on why this is the best form to use..and the safest in my opinion. I have patients divide the 100 mg. capsule as necessary. I believe it is wise to try 1/4 to 1/2 a capsule first and wait to observe if there are any reactions.
Research has also shown lipoic acid to be very effective for these clinical problems:
Thimerasol is a preservative used in vaccinations to increase their self-life. It is about 48% mercury. This substance is being linked to the incredible increase in autism rates currently occuring in the Western world. Here I would like to present six of my favourite books on the subject. This is for YOU the parent to become more informed before you consent to any vaccination regime at all.
N-Acetyl Cysteine (NAC)
Another naturally occurring substance, it is liver friendly and augments the work of glutathione. It also enhances the absorption of glutathione. It is an ultimate component of bodily made glutathione, supplying cysteine, one of the three amino acids, which make up glutathione. The other two being glycine and glutamic acid.
This holds true providing one has no problem metabolizing sulphur containing supplements and foods which unfortunately many mercury patients do.
It has been found in studies of patients with Motor Neuron Disease (MND), Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) that there often is a very high level of circulating cysteine. This high level can interfere with protein function in the nervous system.
Selenium and Vitamin E
Selenium is needed to properly produce the enzyme glutathione peroxidase, (GSH-Px), essential to eliminating mercury from the brain. Studies have shown that the normal high level of unsaturated fatty acids in brain tissue can only be protected by GSH-Px. Depletion of this enzyme and resultant damage may be significant in the development of senility. There are various forms of GSH-Px. The main three are selenium dependent and found in the mitochondria (energy producing entities in the cell) of lipid (fat) cells (i.e. the wrappings of nerve fibres), plasma cells and liver cells. Mercury, cadmium and mercury salts all inhibit every GSH-Px that exists. These not only inhibit the reactive sites for selenium to do its job, but also actually change the structure of the enzyme making it ineffective at its function.
Recent research has indicated that the amino acid methionine is needed to make the organic form of selenium..necessary to increase the production GSH-Px and enhance mercury detoxification.
This is particularly evident in the kidney. In workers who are occupationally exposed to mercury, their mean urinary selenium was lowered. By increasing their selenium, through the diet, urinary mercury excretion increased and blood levels of mercury reduced. In the animal kingdom, those chronically exposed to mercury have inherently higher levels of selenium. Unfortunately, we humans are not very efficient at doing this.An interesting study illustrated the effect mercury and low methionine had on the body’s inflammatory processes. Prostaglandin E1 and thromboxane B2 are indicators of the state of inflammation. The first being "anti-inflammatory" and the second being produced when inflammatory processes are active within the body. In cases of mercury exposure with low methionine, the thromboxane B2 was directly elevated. In time, the Prostaglandin E1 increased slightly in response to the higher thromboxane B2. All symptoms to date attributed to the mercury toxicity syndrome are effects of inflammatory processes.
Selenium also assists in reducing the amount of zinc and copper excreted through the urine in the presence of mercury. It has an immune enhancing effect. We know low levels of Selenium in the diet correlates with increases in cancers such as lymphocytic leukemia, breast, pulmonary, gastrointestinal, colonic, genitourinary, skin and Hodgkin’s disease.
The problem with taking standard selenium supplements, is that it doesn't take much to reach toxic levels.
Lets, start with what I firmly believe does NOT work:
EDTA or ethylenediaminetetraacetic acid is a chemical chelator often used by medical people to treat mercury toxicity. In particular the American College for the Advancement in Medicine, a group of physicians who profess IV chelation is told to use EDTA.
In fact with this protein hampered the nerves cells become entangled, looking just like the lesions we see in Alzheimer’s Disease. They have also seen a direct correlation with the number of amalgams in cadavers and the number of these lesions.
In a scientific paper published in Toxicology and Applied Pharmacology (1993) they further exposed the fact that mercury-EDTA and mercury-EGTA (another derivative) actually "enhanced" mercury’s ability to cause this damage!
Foulkes and Bergman (1993) showed that EDTA could disassociate cadmium from cell membranes but could not do the same for membrane bound mercury. It appears from the research EDTA can help the excretion of lead, manganese, free iron, cadmium and antimony. Therefore, if the mercury is stored in your cell’s membrane (and much is) , then according to these researchers’ work, EDTA remove it.
problem is that commonly now EDTA is IV'd in the form of CaEDTA in a
fast push, leaves too many disassociated metals behind after a rapid
and massive mobilization. The way they compensate for that..if they
know enough to do it..is to use a low dose oral DMSA or DMPS to "scoop"
BAL and D-Penicillamine
BAL (Unithiol) is British Anti-Lewisite an old chemical chelator used years and years ago. It has even more side effects associated with it and mercury redistribution than DMPS and DMSA (to follow). Known as dimercaprol, BAL is a lipid-soluble compound and must be administered in an oil base via very painful, deep muscular injection.
has the same nasty track record and is less effective than the more
DMPS and DMSA are the most commonly used pharmacological chelators used today. Some people have reported doing well with these, particularly when used very carefully and gently. Others, and there is a significant group of these, have been medically devastated by these drugs. I also believe not all adverse reactions are being reported so the truth still remains to be seen as far as ratio of risk to health benefits is concerned, but depending on who you read it could be anywhere from 17 - 25%.
Side effects: occasionally shivering, fever or skin reaction, presumable of an allergic nature, such as itching and exanthema or rash may occur, which are generally reversible on withdrawing treatment.
In isolated cases severe allergic skin reactions (e.g. erythema exudativa multiforme, Stevens-Johnson syndrome) have been reported.
Long-term use of DMPS can influence the mineral balance, especially for elements zinc and copper.
Administration of DMPS causes mobilization of mercury taken up in the body. In isolated cases therefore, clinical symptoms of mercury poisoning may be produced. (and many have fallen terribly ill because of this)
In individual cases there may be raised levels of certain enzymes (transaminases). After ingestion of Dimaval (DMPS) nausea may occur.
Cardiovascular reactions may occur, especially on too rapid injection of DMPS-HEYL and is apparent as a fall in blood pressure, nausea, dizziness and weakness generally a short time after the injection."
Some are very cavalier in that they will tell patients "you have to get worse to get better" or "its just that you are so toxic this is to be expected" when the patient becomes desperately ill.
You would be looking for low back pain (kidney), numbness, aching, brain fog, nausea, headache or in my opinion anything that makes you feel less well than you are. If this happens,
Because normal, needed minerals are chelated out with the mercury (manganese, zinc, magnesium, etc) I have them do six days off, and replenish heavily the minerals with Ortho-Mins, Cardio Mag and Zinc Citrate. . This seems to keep them from getting sick.
I can say however, taking multiple homeopathic combinations is fruitless as far as I’m concerned. These are energetic remedies and basically you are instructing the body to shift in so many directions at the same time that the end result is nothing much happens or the patient gets sicker.
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